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PURE Citrulline Malate Capsules
PURE Citrulline Malate Capsules is backordered and will ship as soon as it is back in stock.
- 2.9 g rof citrulline malate in practical capsule form
- Efficient increase in arginine levels
- Vegan capsules with no unwanted additives
- No caffeine or DMAA
- With silica as an anti-caking agent (production-related)
- Laboratory tested for heavy metals
- Contents: 300 capsules = 60 servings
The amino acid citrulline
Citrulline belongs to the amino acids and was first isolated from watermelons – hence the name, derived from the Latin word for watermelon, "citrullus". The scientific description of this compound goes back to Japanese researchers at the beginning of the 20th century. Watermelons are still considered a natural source of citrulline today.
In human metabolism, citrulline plays a central role in the so-called urea cycle – the biochemical process through which the body excretes excess nitrogen in the form of urea.
Citrulline is also produced as an intermediate during the formation of nitric oxide (NO) from the amino acid arginine. This process is controlled by the enzyme nitric oxide synthase. In the body, citrulline can be converted back into arginine via the urea cycle, making it indirectly available again for NO production.
Citrulline's effect on arginine levels?
Studies in animal models show that supplementation with citrulline can raise arginine levels in the blood more efficiently than direct intake of arginine itself. The reason: a large proportion of arginine is already broken down in the intestine before it reaches the bloodstream.
Citrulline, on the other hand, is largely absorbed unchanged and then converted into arginine in the body – which in turn benefits the body's own nitric oxide synthesis.
In studies with mice, citrulline supplementation achieved higher arginine availability in the blood than direct arginine intake.
"Citrulline supplementation is more efficient at increasing arginine availability than arginine supplementation itself in mice."
– Source
Why combine it with malate?
Citrulline malate is a special form in which citrulline is combined with malate – the salt form of malic acid. Malate is known from apples and also plays a role in the body's energy metabolism.
The combination of citrulline and malate was investigated in a human study published in the British Journal of Sports Medicine. Using magnetic resonance spectroscopy, it was shown that taking citrulline malate for 15 days leads to improved energy supply in the muscles.
"The rate of oxidative ATP production in muscles during training and the rate of PCr recovery after training both increase in subjects who receive citrulline/malate for 15 days. This positive effect of citrulline/malate at the oxidative level may be mediated by malate, an intermediate product of the tricarboxylic acid cycle."
Specifically, it was found that both mitochondrial ATP production during physical activity and phosphocreatine regeneration after exertion were increased. ATP (adenosine triphosphate) is the most important energy source for muscle contractions and physical performance.
Scientists assume that this effect is not due to citrulline alone, but also largely to malate. Malate is an intermediate product of the citric acid cycle – a central part of aerobic energy production. There, it is converted into oxaloacetate, a crucial regulator of the speed of ATP synthesis using oxygen.
Malate is dehydrogenated to oxaloacetate in the citric acid cycle, the concentration of which is one of the most important control variables for the rate of aerobic ATP production.
Combining citrulline with malate not only improves blood flow, but also promotes ATP synthesis in the muscles.
Citrulline malate for athletes?
Citrulline malate is regularly studied for performance support in strength and endurance sports. So far, the results are not consistent – clear and generally applicable intake recommendations, such as for creatine, cannot currently be derived.
Nevertheless, citrulline malate is considered a promising substance for high-intensity training and competition demands.
Individual studies suggest that taking citrulline malate before athletic exertion – for example in tennis – may improve performance. It should be noted that these results were obtained under controlled laboratory conditions. Whether these effects can be transferred one-to-one to real competition situations remains the subject of further research.
"These data suggest that taking citrulline malate before competition may improve tennis players' performance. However, this study used a controlled laboratory environment, so investigating its direct application to performance on the tennis court should be considered."
Frequently asked questions & answers from Edubily
Who should not take citrulline?
People who have problems with the cardiovascular system or have a condition in this area should discuss taking citrulline malate with their doctor.
People with rheumatoid arthritis may have an increased risk of antibodies against citrullinated proteins (ACPA), which can lead to autoimmune reactions. People with elevated glucose levels should also be cautious, as they already have elevated citrulline levels. People with low blood pressure should also avoid citrulline, as it can lower it further.
Why is no arginine included?
Citrulline is enough – it is converted into arginine in the body and at the same time inhibits arginine breakdown. This keeps arginine levels high for longer than with direct arginine intake.
Why not simply take arginine instead of citrulline?
Citrulline is absorbed more efficiently by the body and remains active for longer. This can allow it to have a more sustained effect than pure arginine.
Is the product vegan?
Yes, the PURE Citrulline Malate capsules are 100% vegan, including the capsule shell made from HPMC.
What side effects does citrulline malate have?
Taking it on an empty stomach may cause mild nausea. It is recommended not to take citrulline malate on an empty stomach.
Nutritional values
| Content |
per serving (= 5 capsules) |
|---|---|
| L-citrulline malate | 2,9 g |
| of which L-citrulline | 2 g |
Ingredients
L-citrulline malate, hydroxypropyl methylcellulose (capsule shell), anti-caking agent silicon dioxide.
Recommended use: Take 5 capsules daily, unchewed, either together or in several servings with plenty of liquid.
Notes: Do not exceed the stated recommended daily dose. Keep out of reach of small children. This product is not a substitute for a balanced and varied diet or a healthy lifestyle. Store in a cool, dry and dark place.
Quality & safety to the highest standard
Edubily places great importance on developing and manufacturing products based on a scientifically sound foundation. Its production takes place at experienced partners in Germany and Austria, which are regularly inspected without prior notice and certified according to IFS Food and HACCP. This means Edubily meets strict hygiene and safety requirements. In addition, all products are tested again in independent laboratories for factors such as heavy metals, nutrient levels and possible contaminants. Edubily's aim is not simply to offer just any dietary supplements, but safe and effective ones that benefit health and well-being through well-thought-out formulations and continuous development. This lets fitness athletes and health-conscious people be confident they are getting a high-quality, responsibly designed product.
PURE Citrulline Malate Capsules
PURE Citrulline Malate Capsules is backordered and will ship as soon as it is back in stock.
- 2.9 g rof citrulline malate in practical capsule form
- Efficient increase in arginine levels
- Vegan capsules with no unwanted additives
- No caffeine or DMAA
- With silica as an anti-caking agent (production-related)
- Laboratory tested for heavy metals
- Contents: 300 capsules = 60 servings
The amino acid citrulline
Citrulline belongs to the amino acids and was first isolated from watermelons – hence the name, derived from the Latin word for watermelon, "citrullus". The scientific description of this compound goes back to Japanese researchers at the beginning of the 20th century. Watermelons are still considered a natural source of citrulline today.
In human metabolism, citrulline plays a central role in the so-called urea cycle – the biochemical process through which the body excretes excess nitrogen in the form of urea.
Citrulline is also produced as an intermediate during the formation of nitric oxide (NO) from the amino acid arginine. This process is controlled by the enzyme nitric oxide synthase. In the body, citrulline can be converted back into arginine via the urea cycle, making it indirectly available again for NO production.
Citrulline's effect on arginine levels?
Studies in animal models show that supplementation with citrulline can raise arginine levels in the blood more efficiently than direct intake of arginine itself. The reason: a large proportion of arginine is already broken down in the intestine before it reaches the bloodstream.
Citrulline, on the other hand, is largely absorbed unchanged and then converted into arginine in the body – which in turn benefits the body's own nitric oxide synthesis.
In studies with mice, citrulline supplementation achieved higher arginine availability in the blood than direct arginine intake.
"Citrulline supplementation is more efficient at increasing arginine availability than arginine supplementation itself in mice."
– Source
Why combine it with malate?
Citrulline malate is a special form in which citrulline is combined with malate – the salt form of malic acid. Malate is known from apples and also plays a role in the body's energy metabolism.
The combination of citrulline and malate was investigated in a human study published in the British Journal of Sports Medicine. Using magnetic resonance spectroscopy, it was shown that taking citrulline malate for 15 days leads to improved energy supply in the muscles.
"The rate of oxidative ATP production in muscles during training and the rate of PCr recovery after training both increase in subjects who receive citrulline/malate for 15 days. This positive effect of citrulline/malate at the oxidative level may be mediated by malate, an intermediate product of the tricarboxylic acid cycle."
Specifically, it was found that both mitochondrial ATP production during physical activity and phosphocreatine regeneration after exertion were increased. ATP (adenosine triphosphate) is the most important energy source for muscle contractions and physical performance.
Scientists assume that this effect is not due to citrulline alone, but also largely to malate. Malate is an intermediate product of the citric acid cycle – a central part of aerobic energy production. There, it is converted into oxaloacetate, a crucial regulator of the speed of ATP synthesis using oxygen.
Malate is dehydrogenated to oxaloacetate in the citric acid cycle, the concentration of which is one of the most important control variables for the rate of aerobic ATP production.
Combining citrulline with malate not only improves blood flow, but also promotes ATP synthesis in the muscles.
Citrulline malate for athletes?
Citrulline malate is regularly studied for performance support in strength and endurance sports. So far, the results are not consistent – clear and generally applicable intake recommendations, such as for creatine, cannot currently be derived.
Nevertheless, citrulline malate is considered a promising substance for high-intensity training and competition demands.
Individual studies suggest that taking citrulline malate before athletic exertion – for example in tennis – may improve performance. It should be noted that these results were obtained under controlled laboratory conditions. Whether these effects can be transferred one-to-one to real competition situations remains the subject of further research.
"These data suggest that taking citrulline malate before competition may improve tennis players' performance. However, this study used a controlled laboratory environment, so investigating its direct application to performance on the tennis court should be considered."
Frequently asked questions & answers from Edubily
Who should not take citrulline?
People who have problems with the cardiovascular system or have a condition in this area should discuss taking citrulline malate with their doctor.
People with rheumatoid arthritis may have an increased risk of antibodies against citrullinated proteins (ACPA), which can lead to autoimmune reactions. People with elevated glucose levels should also be cautious, as they already have elevated citrulline levels. People with low blood pressure should also avoid citrulline, as it can lower it further.
Why is no arginine included?
Citrulline is enough – it is converted into arginine in the body and at the same time inhibits arginine breakdown. This keeps arginine levels high for longer than with direct arginine intake.
Why not simply take arginine instead of citrulline?
Citrulline is absorbed more efficiently by the body and remains active for longer. This can allow it to have a more sustained effect than pure arginine.
Is the product vegan?
Yes, the PURE Citrulline Malate capsules are 100% vegan, including the capsule shell made from HPMC.
What side effects does citrulline malate have?
Taking it on an empty stomach may cause mild nausea. It is recommended not to take citrulline malate on an empty stomach.
Nutritional values
| Content |
per serving (= 5 capsules) |
|---|---|
| L-citrulline malate | 2,9 g |
| of which L-citrulline | 2 g |
Ingredients
L-citrulline malate, hydroxypropyl methylcellulose (capsule shell), anti-caking agent silicon dioxide.
Recommended use: Take 5 capsules daily, unchewed, either together or in several servings with plenty of liquid.
Notes: Do not exceed the stated recommended daily dose. Keep out of reach of small children. This product is not a substitute for a balanced and varied diet or a healthy lifestyle. Store in a cool, dry and dark place.
Quality & safety to the highest standard
Edubily places great importance on developing and manufacturing products based on a scientifically sound foundation. Its production takes place at experienced partners in Germany and Austria, which are regularly inspected without prior notice and certified according to IFS Food and HACCP. This means Edubily meets strict hygiene and safety requirements. In addition, all products are tested again in independent laboratories for factors such as heavy metals, nutrient levels and possible contaminants. Edubily's aim is not simply to offer just any dietary supplements, but safe and effective ones that benefit health and well-being through well-thought-out formulations and continuous development. This lets fitness athletes and health-conscious people be confident they are getting a high-quality, responsibly designed product.