PURE Citrulline Malate Capsules

The amino acid citrulline

Citrulline is an amino acid that was first isolated from watermelons—hence its name, which is derived from the Latin word for watermelon, "citrullus." The scientific description of this compound dates back to Japanese researchers in the early 20th century. Watermelons are still considered a natural source of citrulline today.

In human metabolism, citrulline plays a central role in the urea cycle—the biochemical process by which the body excretes excess nitrogen in the form of urea.

In addition, citrulline is produced as an intermediate in the formation of nitric oxide (NO) from the amino acid arginine. This process is regulated by the enzyme nitric oxide synthase. In the body, citrulline can be converted back into arginine via the urea cycle and is thus indirectly available once again for NO production.

Does citrulline affect arginine levels?

Studies in animal models show that citrulline supplementation can raise blood arginine levels more effectively than direct administration of arginine itself. The reason: a large portion of arginine is already broken down in the intestines before it enters the bloodstream.

Citrulline, on the other hand, is absorbed largely unchanged and is then converted into arginine in the body—which in turn supports the body’s own nitric oxide synthesis.

In studies with mice, citrulline supplementation resulted in higher levels of arginine in the blood than direct arginine administration.

"Citrulline supplementation is more effective at increasing arginine availability than arginine supplementation itself in mice."

– Source 

Why combine it with malate?

Citrulline malate is a specific form in which citrulline is combined with malate—the salt form of malic acid. Malate is found in apples and also plays a role in the body’s energy metabolism.

The combination of citrulline and malate was investigated in a human study published inthe British Journal of Sports Medicine. Using magnetic resonance spectroscopy, the study demonstrated that taking citrulline malate over a 15-day period leads to improved energy supply to the muscles.

"The rate of oxidative ATP production in muscles during exercise and the rate of PCr recovery after exercise both increase in subjects who receive citrulline/malate for 15 days. This beneficial effect of citrulline/malate at the oxidative level may be mediated by malate, an intermediate in the tricarboxylic acid cycle."

Specifically, it was found that both mitochondrial ATP production during physical activity and phosphocreatine recovery after exercise were increased. ATP (adenosine triphosphate) is the primary source of energy for muscle contractions and physical performance.

Scientists believe that this effect is not solely due to citrulline, but also largely to malate. Malate is an intermediate product of the citric acid cycle—a central component of aerobic energy production. There, it is converted into oxaloacetate, a key regulator of the rate of ATP synthesis during oxygen consumption.

Malate is oxidized to oxaloacetate in the citric acid cycle, and the concentration of oxaloacetate is one of the most important regulatory factors governing the rate of aerobic ATP production.

Combining citrulline with malate not only improves blood flow but also promotes ATP synthesis in the muscles. 

Citrulline malate for athletes?

Citrulline malate is regularly studied in research on performance enhancement in strength and endurance sports. The results have been inconsistent so far—clear and universally applicable dosage recommendations, such as those for creatine, cannot currently be derived.

Nevertheless, citrulline malate is considered a promising substance for high-intensity training and competition.

Some studies suggest that taking citrulline malate before physical activity—such as tennis—can improve performance. It should be noted, however, that these results were obtained under controlled laboratory conditions. Whether these effects can be directly applied to real-world competitive situations remains a subject for further research.

"These data suggest that taking citrulline malate before a match can improve tennis players' performance. However, this study was conducted in a controlled laboratory setting, so further research is needed to determine how this translates to performance on the tennis court."

–Source: 2016 RCT study 

 

Frequently asked questions and answers from Edubily

Who should not take citrulline?

People who have cardiovascular problems or an existing cardiovascular condition should consult their doctor before taking citrulline malate.

People with rheumatoid arthritis may have an increased risk of developing antibodies against citrullinated proteins (ACPA), which can lead to autoimmune reactions. Similarly, individuals with elevated blood glucose levels should exercise caution, as they already have elevated citrulline levels. People with low blood pressure should also avoid citrulline, as it can further lower their blood pressure.

Why doesn't it contain arginine?

Citrulline is sufficient—it is converted into arginine in the body while simultaneously inhibiting the breakdown of arginine. As a result, arginine levels remain elevated for longer than when arginine is taken directly.

Why not just take arginine instead of citrulline?

Citrulline is absorbed more efficiently by the body and remains active for longer. As a result, it can have a more sustained effect than pure arginine.

Is the product vegan?

Yes, PURE Citrulline Malate capsules are 100% vegan, including the HPMC capsule shell.

What are the side effects of citrulline malate?

Taking it on an empty stomach may cause mild nausea. It is recommended that you do not take citrulline malate on an empty stomach.

 

Nutritional Information

Contents	per serving (= 5 capsules)
L-Citrulline Malate	2,9 g
of which L-citrulline	2 g

Ingredients

L-citrulline malate, hydroxypropyl methylcellulose (capsule shell), anti-caking agent: silica.

Recommended use: Take 5 capsules daily, whole, either all at once or in divided doses, with plenty of water.

Notes: Do not exceed the recommended daily dose. Keep out of reach of small children. This product is not a substitute for a balanced and varied diet and a healthy lifestyle. Store in a cool, dry, and dark place.

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Quality and safety at the highest standard

Edubily attaches great importance to developing and manufacturing products on a scientifically sound basis. Its products are manufactured by experienced partners in Germany and Austria, who are regularly inspected without prior notice and are certified according to IFS Food and HACCP. Edubily thus meets strict hygiene and safety requirements. In addition, all products are checked again in independent laboratories for factors such as heavy metals, nutrient content, and possible contaminants. Edubily's goal is not simply to offer any old dietary supplements, but to provide safe and effective products that promote health and well-being through well-thought-out formulas and continuous development. This means that fitness athletes and health-conscious individuals can be sure that they are getting a high-quality and responsibly designed product.